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Mesenchymal Stem Cells: Miraculous Healers or Dormant Killers?

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Abstract

Mesenchymal Stem Cells (MSCs) are a heterogeneous population of fibroblast-like cells which maintain self-renewability and pluripotency to differentiate into mesodermal cell lineages. The use of MSCs in clinical settings began with high enthusiasm and the number of MSC-based clinical trials has been rising ever since. However; the very unique characteristics of MSCs that made them suitable to for therapeutic use, might give rise to unwanted outcomes, including tumor formation and progression. In this paper, we present a model of carcinogenesis initiated by MSCs, which chains together the tissue organization field theory, the stem cell theory, and the inflammation-cancer chain. We believe that some tissue resident stem cells could be leaked cells from bone marrow MSC pool to various injured tissue, which consequently transform and integrate in the host tissue. If the injury persists or chronic inflammation develops, as a consequence of recurring exposure to growth factors, cytokines, etc. the newly formed tissue from MSCs, which still has conserved their mesenchymal and stemness features, go through rapid population expansion, and nullify their tumor suppressor genes, and hence give rise to neoplastic cell (carcinomas, sarcomas, and carcino-sarcomas). Considering the probability of this hypothesis being true, the clinical and therapeutic use of MSCs should be with caution, and the recipients’ long term follow-up seems to be insightful.

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Acknowledgements

This work was supported by Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences. The Hypothesis was proposed and designed by AG. SA prepared the first draft of the Manuscript. The manuscript was critically reviewed by both AG and SA.

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  1. Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, PO.Box: 71345-1798, Shiraz, Iran

    Abbas Ghaderi & Shabnam Abtahi

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  1. Abbas Ghaderi
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  2. Shabnam Abtahi
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Correspondence to Abbas Ghaderi.

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Ghaderi, A., Abtahi, S. Mesenchymal Stem Cells: Miraculous Healers or Dormant Killers?. Stem Cell Rev and Rep 14, 722–733 (2018). https://doi.org/10.1007/s12015-018-9824-y

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  • DOI: https://doi.org/10.1007/s12015-018-9824-y

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